The Domus Bocca Di Leone is located in Monti, a short walk from Via del Corso, Piazza di Spagna and Spanish Steps. The neighbourhood is well-known for shopping. Rome's attractions, such as Church of Saint Sylvester in Capite and Church of Saint Ivo of the Bretons are within an easy walking distance.

The Domus Bocca Di Leone is a five-minute walk from many attractions including Church of Saint Lawrence's at Lucina, Villa Medici and Church of Saint Athanasius. The hotel is ideally located for sightseeing in Rome with Via Condotti only two minutes away. Guests will find a lot of good restaurants and bars in the surrounding area.